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In vitro activity of the novel Fe-cyclam complex against clinical multidrug-resistant bacterial isolates from Brazil.
Polo, Ana B; Lemos, Ari So; Martins da Mata, Camila Ps; Oliveira, Verônica S; Pontes, Ana Cfb; Pontes, Daniel L; Tavares, Guilherme D; Fabri, Rodrigo L; M Apolônio, Ana Carolina.
Affiliation
  • Polo AB; Institute of Biological Sciences, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, 36036-900, Brazil.
  • Lemos AS; Institute of Biological Sciences, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, 36036-900, Brazil.
  • Martins da Mata CP; Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, 31270-901, Brazil.
  • Oliveira VS; Institute of Chemistry, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, 59078-970, Brazil.
  • Pontes AC; Institute of Chemistry, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, 59078-970, Brazil.
  • Pontes DL; Institute of Chemistry, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, 59078-970, Brazil.
  • Tavares GD; Laboratory of Nanostructured Systems Development, Department of Pharmaceutical Science, Faculty of Pharmacy, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, 36036-900, Brazil.
  • Fabri RL; Institute of Biological Sciences, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, 36036-900, Brazil.
  • M Apolônio AC; Institute of Biological Sciences, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, 36036-900, Brazil.
Future Microbiol ; 18: 897-909, 2023 09.
Article in En | MEDLINE | ID: mdl-37584550
Aim: To evaluate the effect of a new Fe-cyclam complex on pathogenic bacterial species, including multidrug-resistant clinical specimens. Materials & methods: The complex [Fe(cyclam)ox]PF6 (D2) was tested in cytotoxicity and MIC tests. Clinical and reference strains of Gram-negative and Gram-positive bacteria were used. Considering Staphylococcus aureus strains, the profile of antimicrobial susceptibility and time-kill kinetics for D2 was performed. An in silico analysis for D2 was also performed. Results: D2 showed broad bacterial activity, mainly against specimens of Cutibacterium acnes, S. aureus, Pseudomonas aeruginosa and Acinetobacter baumannii. Low cytotoxicity in human cells was demonstrated. Conclusion: The tested compound proved to be a promising agent against resistant bacterial infections.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Acinetobacter baumannii / Anti-Bacterial Agents Limits: Humans Country/Region as subject: America do sul / Brasil Language: En Journal: Future Microbiol Journal subject: MICROBIOLOGIA Year: 2023 Document type: Article Affiliation country: Brazil Country of publication: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Acinetobacter baumannii / Anti-Bacterial Agents Limits: Humans Country/Region as subject: America do sul / Brasil Language: En Journal: Future Microbiol Journal subject: MICROBIOLOGIA Year: 2023 Document type: Article Affiliation country: Brazil Country of publication: United kingdom