Design, synthesis, and evaluation of new benzimidazole    thiourea  derivatives as antitumor agents.

Aboutaleb, Mohamed H; El-Gohary, Nadia S; Ghabbour, Hazem A; El-Kerdawy, Mohamed M

Design, synthesis, and evaluation of new benzimidazole thiourea derivatives as antitumor agents.

Aboutaleb, Mohamed H; El-Gohary, Nadia S; Ghabbour, Hazem A; El-Kerdawy, Mohamed M.

Affiliation

Aboutaleb MH; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
El-Gohary NS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Horus University, New Damietta, Egypt.
Ghabbour HA; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
El-Kerdawy MM; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.

Arch Pharm (Weinheim) ; 356(11): e2300269, 2023 Nov.

Article in En | MEDLINE | ID: mdl-37602810

Subject(s)

Antineoplastic Agents; Leukemia; Humans; Sorafenib/pharmacology; Structure-Activity Relationship; Molecular Docking Simulation; Vascular Endothelial Growth Factor A/pharmacology; Protein Kinase Inhibitors/chemistry; Drug Screening Assays, Antitumor; Antineoplastic Agents/chemistry; Vascular Endothelial Growth Factor Receptor-2; Thiourea/pharmacology; Benzimidazoles/chemistry; Cell Proliferation; Molecular Structure; Drug Design

Key words

antitumor; apoptosis induction; benzimidazoles; molecular docking; multikinase inhibitors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia / Antineoplastic Agents Type of study: Prognostic_studies Limits: Humans Language: En Journal: Arch Pharm (Weinheim) Year: 2023 Document type: Article Affiliation country: Egypt Country of publication: Germany

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