Interferon induction by STING requires its translocation to the late endosomes.

Wang, Chenyao; Sharma, Nikhil; Kessler, Patricia M; Sen, Ganes C

Wang, Chenyao; Sharma, Nikhil; Kessler, Patricia M; Sen, Ganes C.

Affiliation

Wang C; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Sharma N; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Kessler PM; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Sen GC; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.

Traffic ; 24(12): 576-586, 2023 12.

Article in En | MEDLINE | ID: mdl-37658794

Subject(s)

Interferons; Protein Serine-Threonine Kinases; Animals; Protein Serine-Threonine Kinases/genetics; Membrane Proteins/metabolism; Nucleotidyltransferases/genetics; Nucleotidyltransferases/metabolism; Immunity, Innate/genetics; DNA; Endosomes/metabolism; Mammals/genetics; Mammals/metabolism

Key words

EGFR; IRF3; STING signaling; interferon; late endosomes; tyrosine phosphorylation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Interferons / Protein Serine-Threonine Kinases Limits: Animals Language: En Journal: Traffic Journal subject: FISIOLOGIA Year: 2023 Document type: Article Affiliation country: United States Country of publication: United kingdom

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