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Ontogenetic change in the venom composition of one Mexican black-tailed rattlesnake (Crotalus molossus nigrescens) from Durango, Mexico.
Borja, Miguel; Neri-Castro, Edgar; Gutiérrez-Martínez, Arelí; Bledsoe, Richard; Zarzosa, Vanessa; Rodriguez-López, Bruno; Strickland, Jason L; Becerra-López, Jorge; Valenzuela-Ceballos, Sara; Parkinson, Christopher L; Alagón, Alejandro; Castañeda-Gaytán, Gamaliel.
Affiliation
  • Borja M; Facultad de Ciencias Biológicas, Universidad Juárez del Estado de Durango, Av. Universidad s/n. Fracc. Filadelfia, C.P. 35010, Gómez Palacio, Dgo., Mexico.
  • Neri-Castro E; Facultad de Ciencias Biológicas, Universidad Juárez del Estado de Durango, Av. Universidad s/n. Fracc. Filadelfia, C.P. 35010, Gómez Palacio, Dgo., Mexico; Instituto de Biotecnología, Universidad Nacional Autónoma de México, Avenida Universidad 2001, Chamilpa, C.P. 62210, Cuernavaca, Mor., Mexico.
  • Gutiérrez-Martínez A; Facultad de Ciencias Biológicas, Universidad Juárez del Estado de Durango, Av. Universidad s/n. Fracc. Filadelfia, C.P. 35010, Gómez Palacio, Dgo., Mexico.
  • Bledsoe R; Facultad de Ciencias Biológicas, Universidad Juárez del Estado de Durango, Av. Universidad s/n. Fracc. Filadelfia, C.P. 35010, Gómez Palacio, Dgo., Mexico.
  • Zarzosa V; Instituto de Biotecnología, Universidad Nacional Autónoma de México, Avenida Universidad 2001, Chamilpa, C.P. 62210, Cuernavaca, Mor., Mexico.
  • Rodriguez-López B; Facultad de Ciencias Biológicas, Universidad Juárez del Estado de Durango, Av. Universidad s/n. Fracc. Filadelfia, C.P. 35010, Gómez Palacio, Dgo., Mexico.
  • Strickland JL; Department of Biology, University of South Alabama, 5871 USA Dr. N., Mobile, AL, 36688, USA.
  • Becerra-López J; Facultad de Ciencias Biológicas, Universidad Juárez del Estado de Durango, Av. Universidad s/n. Fracc. Filadelfia, C.P. 35010, Gómez Palacio, Dgo., Mexico.
  • Valenzuela-Ceballos S; Facultad de Ciencias Biológicas, Universidad Juárez del Estado de Durango, Av. Universidad s/n. Fracc. Filadelfia, C.P. 35010, Gómez Palacio, Dgo., Mexico.
  • Parkinson CL; Department of Biological Sciences, Clemson University, Clemson, SC, 29634, USA.
  • Alagón A; Instituto de Biotecnología, Universidad Nacional Autónoma de México, Avenida Universidad 2001, Chamilpa, C.P. 62210, Cuernavaca, Mor., Mexico.
  • Castañeda-Gaytán G; Facultad de Ciencias Biológicas, Universidad Juárez del Estado de Durango, Av. Universidad s/n. Fracc. Filadelfia, C.P. 35010, Gómez Palacio, Dgo., Mexico. Electronic address: gamaliel.cg@gmail.com.
Toxicon ; 234: 107280, 2023 Oct.
Article in En | MEDLINE | ID: mdl-37673344
To corroborate the ontogenetic shift in the venom composition of the Mexican Black-tailed Rattlesnake (Crotalus molossus nigrescens) previously reported through the census approach, we evaluated the shift in the protein profile, lethality, and proteolytic and phospholipase activities of four venom samples obtained in 2015, 2018, 2019, and 2021 from one C. m. nigrescens individual (CMN06) collected in Durango, Mexico. We demonstrated that the venom of C. m. nigrescens changed from a myotoxin-rich venom to a phospholipase A2 and snake venom metalloproteinase-rich venom. Additionally, the proteolytic and phospholipase activities increased with age, but the lethality decreased approximately three times.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Country/Region as subject: Mexico Language: En Journal: Toxicon Year: 2023 Document type: Article Affiliation country: Mexico Country of publication: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Country/Region as subject: Mexico Language: En Journal: Toxicon Year: 2023 Document type: Article Affiliation country: Mexico Country of publication: United kingdom