Current Role of Topoisomerase I Inhibitors for the Treatment of Mesenchymal Malignancies and Their Potential Future Use as Payload of Sarcoma-Specific Antibody-Drug Conjugates.

Schöffski, Patrick; Wang, Chao-Chi; Schöffski, Morris Patrick; Wozniak, Agnieszka

Schöffski, Patrick; Wang, Chao-Chi; Schöffski, Morris Patrick; Wozniak, Agnieszka.

Affiliation

Schöffski P; Department of General Medical Oncology, Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.
Wang CC; Department of Oncology, Laboratory of Experimental Oncology, KU Leuven, Leuven, Belgium.
Schöffski MP; Department of Oncology, Laboratory of Experimental Oncology, KU Leuven, Leuven, Belgium.
Wozniak A; Department of Oncology, Laboratory of Experimental Oncology, KU Leuven, Leuven, Belgium.

Oncol Res Treat ; 47(1-2): 18-41, 2024.

Article in En | MEDLINE | ID: mdl-38016427

Subject(s)

Antineoplastic Agents; Immunoconjugates; Rhabdomyosarcoma; Humans; Topoisomerase I Inhibitors/pharmacology; Topoisomerase I Inhibitors/therapeutic use; Irinotecan; Topotecan/pharmacology; Topotecan/therapeutic use; DNA Topoisomerases, Type I/therapeutic use; Vincristine; Temozolomide/therapeutic use; Immunoconjugates/therapeutic use; Neoplasm Recurrence, Local/drug therapy; Rhabdomyosarcoma/drug therapy

Key words

Antibody-drug conjugates; Cytotoxic payload; Sarcoma; Systemic therapy; Topoisomerase I inhibitors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Rhabdomyosarcoma / Immunoconjugates / Antineoplastic Agents Limits: Humans Language: En Journal: Oncol Res Treat Year: 2024 Document type: Article Affiliation country: Belgium Country of publication: Switzerland

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