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Early life exposures contributing to accelerated lung function decline in adulthood - a follow-up study of 11,000 adults from the general population.
Kirkeleit, Jorunn; Riise, Trond; Wielscher, Mathias; Accordini, Simone; Carsin, Anne-Elie; Dratva, Julie; Franklin, Karl A; Garcia-Aymerich, Judith; Jarvis, Deborah; Leynaert, Benedicte; Lodge, Caroline J; Real, Francisco Gomez; Schlünssen, Vivi; Corsico, Angelo Guido; Heinrich, Joachim; Holm, Matthias; Janson, Christer; Benediktsdóttir, Bryndis; Jogi, Rain; Dharmage, Shyamali C; Järvelin, Marjo-Riitta; Svanes, Cecilie.
Affiliation
  • Kirkeleit J; Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway.
  • Riise T; Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
  • Wielscher M; Department of Occupational Medicine and Epidemiology, National Institute of Occupational Health, Oslo, Norway.
  • Accordini S; Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
  • Carsin AE; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
  • Dratva J; Department of Dermatology, Medical University of Vienna, Vienna, Austria.
  • Franklin KA; Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Verona, Italy.
  • Garcia-Aymerich J; ISGlobal, Barcelona, Spain.
  • Jarvis D; Universitat Pompeu Fabra (UPF), Barcelona, Spain.
  • Leynaert B; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.
  • Lodge CJ; Institute of Health Sciences, School of Health Professions, Zürich University of Applied Sciences, Winterthur, Switzerland.
  • Real FG; Medical Faculty, University of Basel, Basel, Switzerland.
  • Schlünssen V; Surgical and Perioperative Sciences, Surgery, Umeå University, Umeå, Sweden.
  • Corsico AG; ISGlobal, Barcelona, Spain.
  • Heinrich J; Universitat Pompeu Fabra (UPF), Barcelona, Spain.
  • Holm M; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.
  • Janson C; National Heart & Lung Institute, Imperial College, London, UK.
  • Benediktsdóttir B; MRC-PHE Centre for Environment and Health, Imperial College, London, UK.
  • Jogi R; Université Paris-Saclay, UVSQ, Univ. Paris-Sud, Inserm, Équipe d'Épidémiologie Respiratoire Intégrative, CESP, Villejuif, France.
  • Dharmage SC; Allergy and Lung Health Unit, School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.
  • Järvelin MR; Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway.
  • Svanes C; Department of Clinical Science, University of Bergen, Bergen, Norway.
EClinicalMedicine ; 66: 102339, 2023 Dec.
Article in En | MEDLINE | ID: mdl-38089857
Background: We aimed to assess whether exposure to risk factors in early life from conception to puberty continue to contribute to lung function decline later in life by using a pooled cohort comprising approx. 11,000 adults followed for more than 20 years and with up to three lung function measurements. Methods: Participants (20-68 years) in the ECRHS and NFBC1966 cohort studies followed in the periods 1991-2013 and 1997-2013, respectively, were included. Mean annual decline in maximum forced expired volume in 1 s (FEV1) and forced vital capacity (FVC) were main outcomes. Associations between early life risk factors and change in lung function were estimated using mixed effects linear models adjusted for sex, age, FEV1, FVC and height at baseline, accounting for personal smoking. Findings: Decline in lung function was accelerated in participants with mothers that smoked during pregnancy (FEV1 2.3 ml/year; 95% CI: 0.7, 3.8) (FVC 2.2 ml/year; 0.2, 4.2), with asthmatic mothers (FEV1 2.6 ml/year; 0.9, 4.4) (FEV1/FVC 0.04 per year; 0.04, 0.7) and asthmatic fathers (FVC 2.7 ml/year; 0.5, 5.0), and in women with early menarche (FVC 2.4 ml/year; 0.4, 4.4). Personal smoking of 10 pack-years contributed to a decline of 2.1 ml/year for FEV1 (1.8, 2.4) and 1.7 ml/year for FVC (1.3, 2.1). Severe respiratory infections in early childhood were associated with accelerated decline among ever-smokers. No effect-modification by personal smoking, asthma symptoms, sex or cohort was found. Interpretation: Mothers' smoking during pregnancy, parental asthma and early menarche may contribute to a decline of FEV1 and FVC later in life comparable to smoking 10 pack-years. Funding: European Union's Horizon 2020; Research Council of Norway; Academy of Finland; University Hospital Oulu; European Regional Development Fund; Spanish Ministry of Science and Innovation; Generalitat de Catalunya.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: EClinicalMedicine Year: 2023 Document type: Article Affiliation country: Norway Country of publication: United kingdom

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: EClinicalMedicine Year: 2023 Document type: Article Affiliation country: Norway Country of publication: United kingdom