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Symptomatic Upper Extremity Peripheral Artery Disease is Associated With Poor Outcomes and a Broad Spectrum of Etiologies.
Armengol, Guillaume; Goudot, Guillaume; Miranda, Sébastien; Benhamou, Ygal; Tafflet, Muriel; Guillet, Henri; Mortelette, Hélène; Levesque, Hervé; Messas, Emmanuel; Mirault, Tristan.
Affiliation
  • Armengol G; Internal Medicine Department, CHU de Rouen, Rouen, France.
  • Goudot G; Vascular Medicine Department, APHP, Centre-Université de Paris, Hôpital Européen Georges-Pompidou, Paris, France.
  • Miranda S; Faculté de Santé, UFR Médecine, Université Paris Cité, Paris, France.
  • Benhamou Y; Physics for Medicine, PSL Research University, Paris, France.
  • Tafflet M; Paris Cardiovascular Research Center, Institut des Sciences Cardiovasculaires, Université Paris Cité, Paris, France.
  • Guillet H; Internal Medicine Department, CHU de Rouen, Rouen, France.
  • Mortelette H; Normandie Univ, Rouen, France.
  • Levesque H; Internal Medicine Department, CHU de Rouen, Rouen, France.
  • Messas E; Normandie Univ, Rouen, France.
  • Mirault T; Paris Cardiovascular Research Center, Institut des Sciences Cardiovasculaires, Université Paris Cité, Paris, France.
Angiology ; : 33197231218332, 2023 Dec 14.
Article in En | MEDLINE | ID: mdl-38096570
The symptomatic upper extremity peripheral artery disease (sUE-PAD) is poorly studied compared with the lower extremity peripheral artery disease (LE-PAD). We aimed to describe sUE-PAD etiologies and outcomes at 2 years. From an observational survey conducted in two French tertiary hospitals, demographic characteristics, etiology, treatment, and outcomes during follow-up were collected on patients with ICD-10 I74.2 code (arterial thrombosis of the upper limbs). We identified 181 patients (53% male, 55 ± 17 years) with hypothenar hammer syndrome (13.8%), cardioembolism (13.3%), atheroma (12.7%), or connective tissue disease (10.5%). No etiology could be found for 16.0% of them. The amputation rate was 13.3%, and lasting symptoms remained at 21.3%. During follow-up, atrial fibrillation occurred in 1 patient and cancer in 4. At 2 years, 59 patients were lost to follow-up, 110 patients were alive, and 12 patients had died. Age and cancer were associated with death. sUE-PAD is not benign, with 20% impaired upper extremity outcome and 10% overall mortality at 2 years. Less frequent than LE-PAD, sUE-PAD presents different characteristics: more women, younger age, and a broad spectrum of etiologies. sUE-PAD requires thorough etiological assessment and is considered to be associated with a severe overall prognosis.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Angiology Year: 2023 Document type: Article Affiliation country: France Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Angiology Year: 2023 Document type: Article Affiliation country: France Country of publication: United States