Synthesis and application of bacterial exopolysaccharides.
Curr Opin Chem Biol
; 78: 102418, 2024 02.
Article
in En
| MEDLINE
| ID: mdl-38134611
ABSTRACT
Exopolysaccharides are produced and excreted by bacteria in the generation of biofilms to provide a protective environment. These polysaccharides are generally generated as heterogeneous polymers of varying length, featuring diverse substitution patterns. To obtain well-defined fragments of these polysaccharides, organic synthesis often is the method of choice, as it allows for full control over chain length and the installation of a pre-determined substitution pattern. This review presents several recent syntheses of exopolysaccharide fragments of Pseudomonas aeruginosa and Staphylococcus aureus and illustrates how these have been used to study biosynthesis enzymes and generate synthetic glycoconjugate vaccines.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Polysaccharides, Bacterial
/
Biofilms
Language:
En
Journal:
Curr Opin Chem Biol
Journal subject:
BIOQUIMICA
Year:
2024
Document type:
Article
Affiliation country:
Netherlands
Country of publication:
United kingdom