Astrocyte signaling and interactions in Multiple Sclerosis.
Curr Opin Cell Biol
; 86: 102307, 2024 02.
Article
in En
| MEDLINE
| ID: mdl-38145604
ABSTRACT
Multiple Sclerosis (MS) is a common cause of impairment in working-aged adults. MS is characterized by neuroinflammation and infiltration of peripheral immune cells to the brain, which cause myelin loss and death of oligodendrocytes and neurons. Many studies on MS have focused on the peripheral immune sources of demyelination and repair. However, recent studies revealed that a glial cell type, the astrocytes, undergo robust morphological and transcriptomic changes that contribute significantly to demyelination and myelin repair. Here, we discuss recent findings elucidating signaling modalities that astrocytes acquire or lose in MS and how these changes alter the interactions of astrocytes with other nervous system cell types.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Multiple Sclerosis
Limits:
Humans
Language:
En
Journal:
Curr Opin Cell Biol
Year:
2024
Document type:
Article
Affiliation country:
United States
Country of publication:
United kingdom