Exploring the mechanism and phytochemicals in Psoraleae Fructus-induced hepatotoxicity based on RNA-seq, in vitro screening and molecular docking.

Shang, Huiying; Liu, Xian; Pan, Jinchao; Cheng, Hongbo; Ma, Zengchun; Xiao, Chengrong; Gao, Yue

Shang, Huiying; Liu, Xian; Pan, Jinchao; Cheng, Hongbo; Ma, Zengchun; Xiao, Chengrong; Gao, Yue.

Affiliation

Shang H; Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, People's Republic of China.
Liu X; Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing, 100850, People's Republic of China.
Pan J; Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing, 100850, People's Republic of China. 1539247436@qq.com.
Cheng H; Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing, 100850, People's Republic of China.
Ma Z; Faculty of Environment and Life Science, Beijing University of Technology, Beijing, 100124, People's Republic of China.
Xiao C; Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing, 100850, People's Republic of China.
Gao Y; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, People's Republic of China.

Sci Rep ; 14(1): 1696, 2024 01 19.

Article in En | MEDLINE | ID: mdl-38242895

Subject(s)

Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Psoralea; Animals; Drugs, Chinese Herbal/chemistry; Molecular Docking Simulation; Psoralea/chemistry; RNA-Seq; Chemical and Drug Induced Liver Injury/drug therapy; Phytochemicals/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drugs, Chinese Herbal / Psoralea / Chemical and Drug Induced Liver Injury Type of study: Diagnostic_studies / Screening_studies Limits: Animals Language: En Journal: Sci Rep Year: 2024 Document type: Article Country of publication: United kingdom

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