Oxygen Targets in Neonatal Pulmonary Hypertension: Individualized, "Precision-Medicine" Approach.
Clin Perinatol
; 51(1): 77-94, 2024 03.
Article
in En
| MEDLINE
| ID: mdl-38325948
ABSTRACT
Oxygen is a specific pulmonary vasodilator. Hypoxemia causes pulmonary vasoconstriction, and normoxia leads to pulmonary vasodilation. However, hyperoxia does not enhance pulmonary vasodilation but causes oxidative stress. There are no clinical trials evaluating optimal oxygen saturation or Pao2 in pulmonary hypertension. Data from translational studies and case series suggest that oxygen saturation of 90% to 97% or Pao2 between 50 and 80 mm Hg is associated with the lowest pulmonary vascular resistance.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oxygen
/
Hypertension, Pulmonary
Limits:
Humans
/
Newborn
Language:
En
Journal:
Clin Perinatol
Year:
2024
Document type:
Article
Country of publication:
United States