Plasma SOMAmer proteomics of postoperative delirium.
Brain Behav
; 14(2): e3422, 2024 02.
Article
in En
| MEDLINE
| ID: mdl-38346717
ABSTRACT
BACKGROUND:
Postoperative delirium is prevalent in older adults and has been shown to increase the risk of long-term cognitive decline. Plasma biomarkers to identify the risk for postoperative delirium and the risk of Alzheimer's disease and related dementias are needed.METHODS:
This biomarker discovery case-control study aimed to identify plasma biomarkers associated with postoperative delirium. Patients aged ≥65 years undergoing major elective noncardiac surgery were recruited. The preoperative plasma proteome was interrogated with SOMAmer-based technology targeting 1433 biomarkers.RESULTS:
In 40 patients (20 with vs. 20 without postoperative delirium), a preoperative panel of 12 biomarkers discriminated patients with postoperative delirium with an accuracy of 97.5%. The final model of five biomarkers delivered a leave-one-out cross-validation accuracy of 80%. Represented biological pathways included lysosomal and immune response functions.CONCLUSION:
In older patients who have undergone major surgery, plasma SOMAmer proteomics may provide a relatively non-invasive benchmark to identify biomarkers associated with postoperative delirium.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Delirium
/
Emergence Delirium
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Aged
/
Humans
Language:
En
Journal:
Brain Behav
Year:
2024
Document type:
Article
Affiliation country:
United States
Country of publication:
United States