Total Synthesis of (±)-Rubriflordilactone A.
J Am Chem Soc
; 146(11): 7198-7203, 2024 Mar 20.
Article
in En
| MEDLINE
| ID: mdl-38456819
ABSTRACT
A new and efficient synthesis of rubriflordilactone A has been realized. The key transformations include the following (1) an intramolecular Prins cyclization to establish the seven-membered ring containing two contiguous stereocenters; (2) a Mukaiyama hydration/oxa-Michael cascade to construct the B-ring; and (3) an unprecedented stereocontrol intermolecular o-QM type [4 + 2]-cycloaddition to rapidly assemble core structure of rubriflordilactone A.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
J Am Chem Soc
Year:
2024
Document type:
Article
Affiliation country:
China
Country of publication:
United States