Brucella infection and Toll-like receptors.
Front Cell Infect Microbiol
; 14: 1342684, 2024.
Article
in En
| MEDLINE
| ID: mdl-38533384
ABSTRACT
Brucella consists of gram-negative bacteria that have the ability to invade and replicate in professional and non-professional phagocytes, and its prolonged persistence in the host leads to brucellosis, a serious zoonosis. Toll-like receptors (TLRs) are the best-known sensors of microorganisms implicated in the regulation of innate and adaptive immunity. In particular, TLRs are transmembrane proteins with a typical structure of an extracellular leucine-rich repeat (LRR) region and an intracellular Toll/interleukin-1 receptor (TIR) domain. In this review, we discuss Brucella infection and the aspects of host immune responses induced by pathogens. Furthermore, we summarize the roles of TLRs in Brucella infection, with substantial emphasis on the molecular insights into its mechanisms of action.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brucella
/
Brucellosis
Limits:
Humans
Language:
En
Journal:
Front Cell Infect Microbiol
Year:
2024
Document type:
Article
Affiliation country:
China
Country of publication:
Switzerland