Headache in Multiple Sclerosis: A Narrative Review.
Medicina (Kaunas)
; 60(4)2024 Mar 30.
Article
in En
| MEDLINE
| ID: mdl-38674218
ABSTRACT
Background:
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disorder of the central nervous system characterized by autoimmune-mediated damage to oligodendrocytes and subsequent myelin destruction. Clinical implications Clinically, the disease presents with many symptoms, often evolving over time. The insidious onset of MS often manifests with non-specific symptoms (prodromal phase), which may precede a clinical diagnosis by several years. Among them, headache is a prominent early indicator, affecting a significant number of MS patients (50-60%).Results:
Headache manifests as migraine or tension-type headache with a clear female predilection (female-male ratio 2-31). Additionally, some disease-modifying therapies in MS can also induce headache. For instance, teriflunomide, interferons, ponesimod, alemtuzumab and cladribine are associated with an increased incidence of headache.Conclusions:
The present review analyzed the literature data on the relationship between headache and MS to provide clinicians with valuable insights for optimized patient management and the therapeutic decision-making process.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Headache
/
Multiple Sclerosis
Limits:
Female
/
Humans
/
Male
Language:
En
Journal:
Medicina (Kaunas)
Journal subject:
MEDICINA
Year:
2024
Document type:
Article
Affiliation country:
Poland
Country of publication:
Switzerland