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Association between Polymorphisms of Heat Shock Protein HSPA5 and Risk of Type 2 Diabetes Mellitus.
Klyosova, E Yu; Azarova, Yu E; Ilyina, E A; Goryainova, N V; Polonikov, A V.
Affiliation
  • Klyosova EY; Kursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia. ecless@yandex.ru.
  • Azarova YE; Kursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia.
  • Ilyina EA; Kursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia.
  • Goryainova NV; Kursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia.
  • Polonikov AV; Kursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia.
Bull Exp Biol Med ; 176(5): 599-602, 2024 Mar.
Article in En | MEDLINE | ID: mdl-38724812
ABSTRACT
We studied the relationship between the HSPA5 gene polymorphisms and the risk of type 2 diabetes mellitus. Genotyping of three SNPs of the HSPA5 gene was performed in 1579 patients with type 2 diabetes mellitus and 1650 healthy individuals. It was found that the genotypes rs55736103-T/T, rs12009-G/G, and rs391957-T/C-T/T are associated with increased risk of type 2 diabetes in females. A rare haplotype, rs55736103C-rs12009A-rs391957T HSPA5, associated with a reduced risk of type 2 diabetes in females was found. Associations between polymorphisms of the HSPA5 gene encoding heat shock protein and the risk of type 2 diabetes mellitus were established for the first time.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genetic Predisposition to Disease / Polymorphism, Single Nucleotide / Diabetes Mellitus, Type 2 / Endoplasmic Reticulum Chaperone BiP / Heat-Shock Proteins Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Bull Exp Biol Med Year: 2024 Document type: Article Affiliation country: RUSSIA Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genetic Predisposition to Disease / Polymorphism, Single Nucleotide / Diabetes Mellitus, Type 2 / Endoplasmic Reticulum Chaperone BiP / Heat-Shock Proteins Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Bull Exp Biol Med Year: 2024 Document type: Article Affiliation country: RUSSIA Country of publication: United States