Hippocampal D1-like dopamine receptor as a novel target for the effect of cannabidiol on extinction and reinstatement of methamphetamine-induced CPP.
Prog Neuropsychopharmacol Biol Psychiatry
; 133: 111025, 2024 Jul 13.
Article
in En
| MEDLINE
| ID: mdl-38729234
ABSTRACT
Methamphetamine (METH) is a major health problem without effective pharmacological treatment. Cannabidiol (CBD), a component of the Cannabis sativa plant, is believed to have the potential to inhibit drug-related behavior. However, the neurobiological mechanisms responsible for the effects of CBD remain unclear. Several studies have proposed that the suppressing effects of CBD on drug-seeking behaviors could be through the modulation of the dopamine system. The hippocampus (HIP) D1-like dopamine receptor (D1R) is essential for forming and retrieving drug-associated memory. Therefore, the present study aimed to investigate the role of D1R in the hippocampal CA1 region on the effects of CBD on the extinction and reinstatement of METH-conditioned place preference (CPP). For this purpose, different groups of rats over a 10-day extinction period were administered different doses of intra-CA1 SCH23390 (0.25, 1, or 4 µg/0.5 µl, Saline) as a D1R antagonist before ICV injection of CBD (10 µg/5 µl, DMSO12%). In addition, a different set of animals received intra-CA1 SCH23390 (0.25, 1, or 4 µg/0.5 µl) before CBD injection (50 µg/5 µl) on the reinstatement day. The results revealed that the highest dose of SCH23390 (4 µg) significantly reduced the accelerating effects of CBD on the extinction of METH-CPP (P < 0.01). Furthermore, SCH23390 (1 and 4 µg) in the reinstatement phase notably reversed the preventive effects of CBD on the reinstatement of drug-seeking behavior (P < 0.05 and P < 0.001, respectively). In conclusion, the current study revealed that CBD made a shorter extinction period and suppressed METH reinstatement in part by interacting with D1-like dopamine receptors in the CA1 area of HIP.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Benzazepines
/
Cannabidiol
/
Receptors, Dopamine D1
/
Rats, Wistar
/
Extinction, Psychological
/
Methamphetamine
Limits:
Animals
Language:
En
Journal:
Prog Neuropsychopharmacol Biol Psychiatry
/
Prog. neuropsychopharmacol. biol psychiatr
/
Progress in neuro-psychopharmacology & biological psychiatry
Year:
2024
Document type:
Article
Affiliation country:
Iran
Country of publication:
United kingdom