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Alpha-Gal syndrome as a novel food allergy: a case report study.
Ghelichi-Ghojogh, Mousa; Ghezeljeh, Edris; Delavari, Sahar; Aghapour, Seyed Ali.
Affiliation
  • Ghelichi-Ghojogh M; Neonatal and Children's Health Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
  • Ghezeljeh E; Neonatal and Children's Health Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
  • Delavari S; Institute for the Developing Mind, Children's Hospital Los Angeles, Keck School of Medicine at the University of Southern California, Los Angeles, CA.
  • Aghapour SA; Neonatal and Children's Health Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
Ann Med Surg (Lond) ; 86(6): 3624-3626, 2024 Jun.
Article in En | MEDLINE | ID: mdl-38846906
ABSTRACT
Introduction and importance Alpha-Gal syndrome (AGS), a distinct form of mammalian meat allergy, presents unique characteristics that set it apart from typical IgE-mediated food hypersensitivities. AGS induces an allergic response typically 3-6 h post-ingestion of mammalian meat, such as beef, pork, or lamb. This prolonged reaction time differentiates AGS from other food allergies, which usually provoke a more immediate response. Case presentation The authors present a case of a 35-year-old male patient who, unbeknownst to him, had been experiencing symptoms consistent with Alpha-Gal allergy for several years. His symptoms only subsided upon the complete elimination of mammalian meat from his diet. It was only then that the possibility of AGS was considered. Complete abstinence from mammalian meat, meat by-products, and other α-Gal containing foods is the most effective preventative strategy for AGS. No definitive cure for AGS has been established as of now. Treatment protocols for hypersensitivity reactions are contingent upon the severity of the reaction, with therapies ranging from antihistamine medications to the administration of epinephrine.

Conclusion:

There is considerable variability among AGS patients concerning the consumption of dairy products. Some individuals with AGS can safely consume dairy products without any adverse reactions, while others are advised to abstain due to potential allergenic responses. This variability in dairy tolerance among AGS patients warrants further investigation.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Ann Med Surg (Lond) Year: 2024 Document type: Article Affiliation country: Iran Country of publication: United kingdom

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Ann Med Surg (Lond) Year: 2024 Document type: Article Affiliation country: Iran Country of publication: United kingdom