Mast cells: The Janus of type 2 inflammation.

Kotrba, Johanna; Dudeck, Anne

Kotrba, Johanna; Dudeck, Anne.

Affiliation

Kotrba J; Institute for Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke University, Magdeburg, Germany.
Dudeck A; Institute for Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke University, Magdeburg, Germany; Health Campus Immunology, Infectiology and Inflammation, Otto-von-Guericke University, Magdeburg, Germany. Electronic address: anne.dudeck@med.ovgu.de.

Immunity ; 57(6): 1182-1184, 2024 Jun 11.

Article in En | MEDLINE | ID: mdl-38865961

ABSTRACT

ABSTRACT

Mast cells (MCs) are effectors in type 2 immunity, well known for their detrimental roles in allergy. In this issue of Immunity, Alhallak et al. now identify a protective role of MCs against exacerbated immune responses mediated by prostaglandin E2 (PGE2)-driven soluble ST2.

Subject(s)

Inflammation; Mast Cells; Mast Cells/immunology; Animals; Humans; Inflammation/immunology; Dinoprostone/metabolism; Dinoprostone/immunology; Interleukin-1 Receptor-Like 1 Protein/metabolism; Interleukin-1 Receptor-Like 1 Protein/immunology; Mice; Receptors, Cell Surface/metabolism; Receptors, Cell Surface/immunology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Inflammation / Mast Cells Limits: Animals / Humans Language: En Journal: Immunity Journal subject: ALERGIA E IMUNOLOGIA Year: 2024 Document type: Article Affiliation country: Germany Country of publication: United States

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