Palladium-Catalyzed Enantioselective Migratory Hydroamidocarbonylation of Amide-Linked Alkenes to Access Chiral α-Alkyl Succinimides.
Angew Chem Int Ed Engl
; : e202410967, 2024 Jul 15.
Article
in En
| MEDLINE
| ID: mdl-39007709
ABSTRACT
A Pd-catalyzed asymmetric isomerization-hydroamidocarbonylation of amide-containing alkenes was developed, affording a variety of chiral a-alkyl succinimides in moderate to good yields with high enantioselectivities. The key to success was introducing bulky 1-adamentyl P-substitution and 2,3,5,6-tetramethoxyphenyl group into the rigid P-chirogenic bisphosphine ligand to create stronger steric hinderance and deeper catalytic pocket. By this approach, regio- or stereo-convergent synthesis of enantiomeric succinimides from the mixture of olefin isomers was achieved.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Angew Chem Int Ed Engl
Year:
2024
Document type:
Article
Affiliation country:
China
Country of publication:
Germany