Separation of reproductive decline from lifespan extension during methionine restriction.
Nat Aging
; 4(8): 1089-1101, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-39060538
ABSTRACT
Lifespan-extending interventions are generally thought to result in reduced fecundity. The generality of this principle and how it may extend to nutrition and metabolism is not understood. We considered dietary methionine restriction (MR), a lifespan-extending intervention linked to Mediterranean and plant-based diets. Using a chemically defined diet that we developed for Drosophila melanogaster, we surveyed the nutritional landscape in the background of MR and found that folic acid, a vitamin linked to one-carbon metabolism, notably was the lone nutrient that restored reproductive capacity while maintaining lifespan extension. In vivo isotope tracing, metabolomics and flux analysis identified the tricarboxylic cycle and redox coupling as major determinants of the MR-folic acid benefits, in part, as they related to sperm function. Together these findings suggest that dietary interventions optimized for longevity may be separable from adverse effects such as reproductive decline.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Reproduction
/
Drosophila melanogaster
/
Folic Acid
/
Longevity
/
Methionine
Limits:
Animals
Language:
En
Journal:
Nat Aging
Year:
2024
Document type:
Article
Affiliation country:
United States