A new in vitro uranium sequestration assay to analyze the effectiveness of 3,4,3-LI(1,2-HOPO) in reducing the harmful effects of this actinide on bone cells.
Environ Toxicol Pharmacol
; 110: 104518, 2024 Sep.
Article
in En
| MEDLINE
| ID: mdl-39067717
ABSTRACT
Environmental or occupational exposure to natural uranium can have adverse health effects, with its chemical toxicity being mainly directed towards the kidneys and skeleton. This has led to the development of chelating agents to remove uranium from the human body, including the ligand 3,4,3-LI(1,2-HOPO). We have developed a new in vitro assay to assess the efficacy of 3,4,3-LI(1,2-HOPO) in attenuating uranium-induced bone cell damage. This approach uses osteoclasts whose formation and function are altered by exposure to uranium. This assay is an interesting and effective alternative to animal methods for assessing the efficacy and safety of new uranium decorporants.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Osteoclasts
/
Uranium
Limits:
Animals
/
Humans
Language:
En
Journal:
Environ Toxicol Pharmacol
Year:
2024
Document type:
Article
Country of publication:
Netherlands