Association between exposure to organophosphate pesticides and cytokine levels in a population of flower workers in Mexico.
Environ Toxicol Pharmacol
; 110: 104521, 2024 Sep.
Article
in En
| MEDLINE
| ID: mdl-39069195
ABSTRACT
The ability of organophosphate pesticides to disturb immune function has been demonstrated by in vivo and in vitro studies, but evidence of such effects on humans remains scarce. To assess the association between organophosphate pesticides exposure and cytokine levels in Mexican flower workers, a cross-sectional study was carried out. A questionnaire was provided to 121 male flower workers, and urine and blood samples were collected. Using gas chromatography, urinary concentrations of dialkylphosphate metabolites were determined. The serum cytokine levels, IL-4, IL-5, IL-6, IL-8, and IL-10, were measured using multiplex analysis, and levels of INF-γ and TNF-α by ELISA. We found that a higher dialkylphosphate concentration decreased the pro-inflammatory cytokines INF-γ (ß = -0.63; 95â¯% CI -1.22, -0.05), TNF-α (ß= -1.18; 95â¯% CI -2.38, 0.02), and IL-6 (ß= -0.59; 95â¯% CI -1.29, 0.12), and increased IL-10 (ß=0.56; 95â¯% CI 0.02, 1.09), the main anti-inflammatory cytokine, suggesting an imbalance of the immune response in flower workers.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pesticides
/
Cytokines
/
Occupational Exposure
Limits:
Adult
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Mexico
Language:
En
Journal:
Environ Toxicol Pharmacol
/
Environ. toxicol. pharmacol
/
Environmental toxicology and pharmacology
Year:
2024
Document type:
Article
Country of publication:
Netherlands