Electrochemical Determination of Cyclobenzaprine Hydrochloride Muscle Relaxant Using Novel S-GCN/TiO2-Based Carbon Electrode.
ACS Omega
; 9(29): 31657-31668, 2024 Jul 23.
Article
in En
| MEDLINE
| ID: mdl-39072069
ABSTRACT
We have successfully prepared the titanium dioxide (TiO2) nanoparticles (NPs) and sulfur-incorporated graphitic carbon nitride (S-GCN)-modified carbon paste electrode (CPE). The CPEs modified with TiO2 NPs and S-GCN were employed for detecting and quantifying the skeletal muscle relaxant cyclobenzaprine hydrochloride (CBP) using cyclic voltammetry and square wave voltammetry (SWV) techniques. Optimal electrochemical conditions were indicated by the pH study results, with the highest peak current observed at a physiological pH of 7.4. The electrochemical process was determined to involve an equivalent number of protons (H+) and electrons (e-). The concentration variation of CBP (ranging from 0.06 to 10 × 10-7 mol L-1) was explored using SWV. The limits of detection and quantification were determined as 6.4 × 10-9 and 2.1 × 10-8 M, respectively. The proposed electrode configuration was applied to analyze real samples, including water, biomedical, and pharmaceutical specimens.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
ACS Omega
Year:
2024
Document type:
Article
Affiliation country:
India
Country of publication:
United States