In vitro interactions of combinations of colistin with meropenem, rifampicin and tigecycline in colistin-resistant, biofilm-forming Klebsiella pneumoniae.
Diagn Microbiol Infect Dis
; 110(2): 116408, 2024 Oct.
Article
in En
| MEDLINE
| ID: mdl-39079190
ABSTRACT
In this study, it was aimed to reveal the in vitro interactions of combinations of colistin with meropenem, rifampicin and tigecycline in colistin-resistant, biofilm-forming Klebsiella pneumonia. A total of 30 isolates, 15 of which formed biofilms and 15 did not form biofilms, were randomly selected from K. pneumoniae isolates growing in blood samples. The synergy rates of colistin-meropenem, colistin-tigecycline, colistin-rifampicin combinations in planktonic/sessile bacteria are; It was determined as 83,3%/73,3%, 66,6%/33,3%, 100%/60% respectively. Biofilm inhibitory concentration (BIC) of colistin, meropenem, tigecycline, and rifampicin significantly increased after biofilm formation. The synergistic activity seen in the sessile form was independent of the planktonic form. Although a high synergistic effect was observed in the meropenem-colistin combination on sessile bacteria, colistin had very high BIC ââin all combinations. Large-scale studies are needed in which the number of isolates studied is large, bacterial resistance profiles are evaluated genomically, and various antimicrobial groups are included.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Rifampin
/
Klebsiella Infections
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Microbial Sensitivity Tests
/
Colistin
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Biofilms
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Drug Synergism
/
Meropenem
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Tigecycline
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Klebsiella pneumoniae
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Anti-Bacterial Agents
Limits:
Humans
Language:
En
Journal:
Diagn Microbiol Infect Dis
Year:
2024
Document type:
Article
Country of publication:
United States