Pure large-cell neuroendocrine carcinoma of the ovary with a somatic BRCA1 mutation: The first reported case and the review of the literature.
SAGE Open Med Case Rep
; 12: 2050313X241266415, 2024.
Article
in En
| MEDLINE
| ID: mdl-39091963
ABSTRACT
Pure large-cell neuroendocrine carcinomas of the ovary are extremely rare, so there is a lack of molecular information on this type of cancer. Herein, we presented a pure primary large-cell neuroendocrine carcinomas of the ovary in a 72-year-old female with a pathogenic somatic mutation at the c.5332+1g>a splice site of the BRCA1 gene and with no TP53 mutation. She was uneventful 32 months after the operation and chemotherapies. To the best of our knowledge, this is the first report of a BRCA1 somatic mutation in the ovary large-cell neuroendocrine carcinomas. Testing BRCA1/2 mutations in patients with large ovarian cell neuroendocrine carcinomas might provide an opportunity for their future target treatments. It would expand our understanding.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
SAGE Open Med Case Rep
Year:
2024
Document type:
Article
Affiliation country:
China
Country of publication:
United kingdom