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Physicochemical properties and antibiofilm activity of mineral trioxide aggregate associated with farnesol.
Castro-Núñez, Gabriela Mariana; Tanomaru-Filho, Mário; Chávez-Andrade, Gisselle Moraima; Torres, Fernanda Ferrari Esteves; Bosso-Martelo, Roberta; Guerreiro-Tanomaru, Juliane Maria.
Affiliation
  • Castro-Núñez GM; Universidad Catolica de Santa Maria - UCSM, School of Dentistry, Arequipa, Peru.
  • Tanomaru-Filho M; Universidade Estadual Paulista - UNESP, School of Dentistry, Department of Restorative Dentistry, Araraquara, SP, Brazil.
  • Chávez-Andrade GM; Universidade Estadual Paulista - UNESP, School of Dentistry, Department of Restorative Dentistry, Araraquara, SP, Brazil.
  • Torres FFE; Universidade Estadual Paulista - UNESP, School of Dentistry, Department of Restorative Dentistry, Araraquara, SP, Brazil.
  • Bosso-Martelo R; Universidade Federal da Bahia - UFBA, School of Dentistry, Department of Dentistry, Salvador, BA, Brazil.
  • Guerreiro-Tanomaru JM; Universidade Estadual Paulista - UNESP, School of Dentistry, Department of Restorative Dentistry, Araraquara, SP, Brazil.
Braz Oral Res ; 38: e066, 2024.
Article in En | MEDLINE | ID: mdl-39109763
ABSTRACT
This study assessed the physicochemical and antibiofilm properties of white mineral trioxide aggregate (MTA) associated with 1 or 2% of farnesol. Setting time was evaluated based on ISO 6876/2012. Radiopacity was evaluated by radiographic analysis. pH was assessed after time intervals of 1, 3, 7, 14, 21, and 28 days. Solubility (% mass loss) and volumetric change (by micro-CT) of the cements were evaluated after immersion in distilled water. The presence of voids inside the materials was assessed by using micro-CT. Antibiofilm activity against Enterococcus faecalis was evaluated by crystal violet assay and the modified direct contact test performed with biofilm previously formed on bovine root dentin for 14 days. Data were submitted to ANOVA/Tukey tests with 5% significance level. The incorporation of farnesol into MTA increased its setting time, but decreased its solubility at 30 days and its volumetric loss in all periods (p < 0.05). Radiopacity and solubility after 7 days were similar among the materials (p > 0.05). The association of farnesol showed the highest pH value after 1 and 3 days (p < 0.05). The association of farnesol with MTA promoted a decrease in the presence of voids, and increased the antimicrobial activity on biofilm biomass of E. faecalis (p < 0.05). In conclusion, the addition of farnesol can be suggested to improve the antimicrobial properties and the consistency of MTA.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxides / Root Canal Filling Materials / Solubility / Materials Testing / Enterococcus faecalis / Silicates / Calcium Compounds / Aluminum Compounds / Biofilms / Drug Combinations Limits: Animals Language: En Journal: Braz Oral Res Journal subject: ODONTOLOGIA Year: 2024 Document type: Article Affiliation country: Peru Country of publication: Brazil

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxides / Root Canal Filling Materials / Solubility / Materials Testing / Enterococcus faecalis / Silicates / Calcium Compounds / Aluminum Compounds / Biofilms / Drug Combinations Limits: Animals Language: En Journal: Braz Oral Res Journal subject: ODONTOLOGIA Year: 2024 Document type: Article Affiliation country: Peru Country of publication: Brazil