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A pattern emerges in chromatin aging: AP-1 steals the show.
Lynch, Cian J; Richart, Laia; Serrano, Manuel.
Affiliation
  • Lynch CJ; Altos Labs, Cambridge Institute of Science, Granta Park, Cambridge CB21 6GP, UK.
  • Richart L; Altos Labs, Cambridge Institute of Science, Granta Park, Cambridge CB21 6GP, UK.
  • Serrano M; Altos Labs, Cambridge Institute of Science, Granta Park, Cambridge CB21 6GP, UK. Electronic address: mserrano@altoslabs.com.
Cell Metab ; 36(8): 1639-1641, 2024 Aug 06.
Article in En | MEDLINE | ID: mdl-39111283
ABSTRACT
During aging, transcriptional programs of cell identity are partially eroded, reducing cellular fitness and resilience. Patrick et al.1 unveil a general mechanism for this process that consists of the progressive loss of transcription factor AP-1 from cell identity enhancers and its relocation by competition to stress-response elements.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chromatin / Transcription Factor AP-1 Limits: Animals / Humans Language: En Journal: Cell Metab Journal subject: METABOLISMO Year: 2024 Document type: Article Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chromatin / Transcription Factor AP-1 Limits: Animals / Humans Language: En Journal: Cell Metab Journal subject: METABOLISMO Year: 2024 Document type: Article Country of publication: United States