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Patient characteristics, treatment patterns, and survival outcomes for patients with malignant pleural mesothelioma in Denmark between 2011 and 2018: a nationwide population-based cohort study.
Sørensen, Jens Benn; Baas, Paul; Szépligeti, Szimonetta Komjáthiné; Pedersen, Alma B; Johnsen, Søren P; Carroll, Robert; Schoemaker, Minouk J; Rault, Caroline; Daumont, Melinda J; Ehrenstein, Vera.
Affiliation
  • Sørensen JB; Department of Oncology, Rigshospitalet, Copenhagen, Denmark. Jens.Benn.Soerensen@regionh.dk.
  • Baas P; Department of Thoracic Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
  • Szépligeti SK; Department of Clinical Epidemiology, Aarhus University and Aarhus University Hospital, Aarhus, Denmark.
  • Pedersen AB; Department of Clinical Epidemiology, Aarhus University and Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
  • Johnsen SP; Danish Center for Health Services Research, Department for Clinical Medicine, Aalborg University Aalborg, Denmark.
  • Carroll R; Centre for Observational Research and Data Science, Bristol Myers Squibb, Uxbridge, UK.
  • Schoemaker MJ; Real World Solutions, IQVIA, Amsterdam, The Netherlands.
  • Rault C; Data Gnosis, Rennes, France.
  • Daumont MJ; Worldwide Health Economics & Outcomes Research, Bristol Myers Squibb, Braine-L'Alleud, Belgium.
  • Ehrenstein V; Department of Clinical Epidemiology, Aarhus University and Aarhus University Hospital, Aarhus, Denmark.
Acta Oncol ; 63: 649-657, 2024 Aug 08.
Article in En | MEDLINE | ID: mdl-39114950
ABSTRACT

BACKGROUND:

Malignant pleural mesothelioma (MPM) is a rare thoracic malignancy with poor prognosis and limited treatment options. Immunotherapy shows potential for improved outcomes; however, real-world evidence on its use will take time to accumulate. This study examined patient characteristics, treatment patterns, overall survival (OS), and predictors of mortality among patients diagnosed with MPM in Denmark prior to the introduction of newer treatments.

METHODS:

This historical cohort study based on routinely collected Danish National Registry data included adults newly diagnosed with MPM between 01 January 2011 and 31 May 2018. Summary statistics were used to describe patient characteristics and initial treatment. OS was estimated using Kaplan-Meier methods; Cox regression was used to compare patient mortality against the (age/sex-matched) general population and to investigate mortality predictors.

RESULTS:

Overall, 880 patients were included; 44% had advanced MPM, 37% had non-advanced MPM, and 19% had unknown MPM stage. Median age at diagnosis was 71.9 years, and 82% of the patients were male. Within 180 days of diagnosis, no treatment was recorded for 215 patients (54%) with advanced MPM and 150 (46%) with non-advanced MPM. Median time-to-initial treatment (interquartile range) was 47 days (31-111) overall, 40 days (28-77) in patients with advanced MPM, and 53 days (35-121) with non-advanced MPM. Median OS was 13.7 months overall (non-advanced MPM 18.0 months vs. advanced MPM 10.0 months). Predictors of higher mortality were older age at diagnosis, histology, and advanced MPM stage.

INTERPRETATION:

These findings provide a baseline upon which to evaluate MPM epidemiology as newer treatments are adopted in routine practice.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pleural Neoplasms / Registries / Mesothelioma, Malignant Limits: Aged / Aged80 / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: En Journal: Acta Oncol Journal subject: NEOPLASIAS Year: 2024 Document type: Article Affiliation country: Denmark Country of publication: Sweden

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pleural Neoplasms / Registries / Mesothelioma, Malignant Limits: Aged / Aged80 / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: En Journal: Acta Oncol Journal subject: NEOPLASIAS Year: 2024 Document type: Article Affiliation country: Denmark Country of publication: Sweden