Point Mutations in the M Domain of PCID2 Impair Its Function in mRNA Export in Drosophila melanogaster.
Dokl Biol Sci
; 518(1): 112-115, 2024 Oct.
Article
in En
| MEDLINE
| ID: mdl-39128950
ABSTRACT
The PCID2 protein is a component of the eukaryotic TREX-2 complex, which is responsible for mRNA export from the nucleus into the cytoplasm. We have previously shown that Drosophila melanogaster PCID2 is involved in specific mRNA recognition and identified the key amino acids responsible for its interaction with the ras2 RNA. In this work, point mutations of the amino acids were shown to disrupt the PCID2 interaction with cell RNAs and to distort the export of polyA-containing mRNAs from the nucleus into the cytoplasm in Drosophila cells.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
RNA, Messenger
/
Point Mutation
/
Drosophila Proteins
/
Drosophila melanogaster
Limits:
Animals
Language:
En
Journal:
Dokl Biol Sci
Year:
2024
Document type:
Article
Affiliation country:
RUSSIA
Country of publication:
United States