Relationship Between Retinal Oxygen Saturation and the Severity of Visual Field Damage in Glaucoma.
J Glaucoma
; 33(10): 728-734, 2024 Oct 01.
Article
in En
| MEDLINE
| ID: mdl-39133058
ABSTRACT
PRCIS Increased oxygen saturation (StO 2 ) was significantly associated with the severity of visual field (VF) damage in patients with glaucoma. OBJECTIVE:
To investigate the association between retinal StO 2 percentage and the severity of VF loss in glaucoma.METHODS:
A total of 198 eyes from 131 patients with glaucoma were included in this cross-sectional study. Participants underwent imaging using ocular oximetry (Zilia) and 24-2 Swedish Interactive Threshold Algorithm standard VF (Carl Zeiss-Meditec). StO 2 (%) was measured at 2 locations of the peripapillary optic nerve head (superotemporal, and inferotemporal). Measurements were reported as the mean of at least 5 measurements in each location. Associations between the severity of VF loss, reported as mean deviation, and StO 2 (%) were calculated.RESULTS:
A total of 198 eyes of 131 patients (mean (95% CI) age, 71.1 (68.9,73.3) years, 68 females (51.9%), and 63 males (48.1%) were analyzed. In univariable analysis, higher StO 2 -0.06 (-0.12, 0.00) was associated with severity in all hemifields ( P = 0.047). Multivariate regression analysis showed that each 1% increase in StO 2 was associated with -0.06 (-0.12, -0.00) dB loss in mean deviation in all hemifields ( P = 0.043). In multivariate regression analysis in the superior hemifields, higher StO 2 -0.07 (-0.16, 0.01) tended to be associated with superior hemifield severity ( P = 0.09).CONCLUSIONS:
Retinal oximetry enabled the continuous quantitative measurement of retinal StO 2. Increased StO 2 was significantly associated with the severity of VF damage in patients with glaucoma.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Vision Disorders
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Oximetry
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Visual Fields
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Visual Field Tests
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Oxygen Saturation
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Intraocular Pressure
Limits:
Aged
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Female
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Humans
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Male
/
Middle aged
Language:
En
Journal:
J Glaucoma
Journal subject:
OFTALMOLOGIA
Year:
2024
Document type:
Article
Affiliation country:
Canada
Country of publication:
United States