SuFEx-Functionalized Quinones via Ruthenium-Catalyzed C-H Alkenylation: A Potential Building Block for Bioactivity Valorization.
Chem Asian J
; : e202400757, 2024 Aug 13.
Article
in En
| MEDLINE
| ID: mdl-39136413
ABSTRACT
Herein, we describe the Ru-catalyzed C-H alkenylation of 1,4-naphthoquinones (1,4-NQs), resulting in 1,4-naphthoquinoidal/SuFEx hybrids with moderate to good yields. This method provides a novel route for direct access to ethenesulfonyl-fluorinated quinone structures. We conducted mechanistic studies to gain an in-depth understanding of the elementary steps of the reaction. Additionally, we evaluated the prototypes against trypomastigote forms of T. cruzi, leading to the identification of compounds with potent trypanocidal activity.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Chem Asian J
/
Chem. - Asian j. (Internet)
/
Chemistry - an Asian journal (Internet)
Year:
2024
Document type:
Article
Affiliation country:
Brazil
Country of publication:
Germany