Pyrrololactam alkaloids with IL-6 inhibitory activities from the sponge Phakellia fusca collected in the South China Sea.
Phytochemistry
; 228: 114250, 2024 Dec.
Article
in En
| MEDLINE
| ID: mdl-39168424
ABSTRACT
Sixteen undescribed pyrrololactam alkaloids, including five 2-bromopyrrole-ε-lactam (1a, 1b, 4a, 4b and 5), two 3-bromopyrrole-ε-lactam (9 and 10), eight pyrrole-ε-lactam (2a-3 and 6a-8), and one pyrrole-δ-lactam alkaloids (11), along with three previously reported compounds (12-14) were isolated from the marine sponge Phakellia fusca collected in the South China Sea. The planar structures were determined by NMR and MS analyses, while the absolute configurations were clearly elucidated by comparing the experimental and calculated ECD spectra. Compounds 2a, 2b, 4a-7b, 10, 12 and 13 exhibited anti-inflammatory activity in inhibiting the production of inflammatory cytokines IL-6 in LPS-induced RAW264.7 macrophages.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Porifera
/
Pyrroles
/
Interleukin-6
/
Alkaloids
/
Lactams
Limits:
Animals
Country/Region as subject:
Asia
Language:
En
Journal:
Phytochemistry
Year:
2024
Document type:
Article
Affiliation country:
China
Country of publication:
United kingdom