Ubiquitin gets sweet: Sugar-mediated ubiquitination regulates Nrf1 function.

Mody, Alison C; Woo, Christina M

Mody, Alison C; Woo, Christina M.

Affiliation

Mody AC; Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford St, Cambridge, MA 02138, USA.
Woo CM; Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford St, Cambridge, MA 02138, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: cwoo@chemistry.harvard.edu.

Mol Cell ; 84(16): 3003-3005, 2024 Aug 22.

Article in En | MEDLINE | ID: mdl-39178835

ABSTRACT

ABSTRACT

In this issue of Molecular Cell, Yoshida et al.1 report an unconventional sugar-dependent ubiquitination event on Nrf1 that disrupts Nrf1 transcriptional activation.

Subject(s)

Ubiquitin; Ubiquitination; Humans; Ubiquitin/metabolism; Nuclear Respiratory Factor 1/metabolism; Nuclear Respiratory Factor 1/genetics; Sugars/metabolism; Transcriptional Activation; Animals

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ubiquitin / Ubiquitination Limits: Animals / Humans Language: En Journal: Mol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2024 Document type: Article Affiliation country: United States Country of publication: United States

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