Gasdermins as evolutionarily conserved executors of inflammation and cell death.
Nat Cell Biol
; 26(9): 1394-1406, 2024 Sep.
Article
in En
| MEDLINE
| ID: mdl-39187689
ABSTRACT
The gasdermins are a family of pore-forming proteins that have recently emerged as executors of pyroptosis, a lytic form of cell death that is induced by the innate immune system to eradicate infected or malignant cells. Mammalian gasdermins comprise a cytotoxic N-terminal domain, a flexible linker and a C-terminal repressor domain. Proteolytic cleavage in the linker releases the cytotoxic domain, thereby allowing it to form ß-barrel membrane pores. Formation of gasdermin pores in the plasma membrane eventually leads to a loss of the electrochemical gradient, cell death and membrane rupture. Here we review recent work that has expanded our understanding of gasdermin biology and function in mammals by revealing their activation mechanism, their regulation and their roles in autoimmunity, host defence and cancer. We further highlight fungal and bacterial gasdermin pore formation pointing to a conserved mechanism of cell death induction.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pyroptosis
/
Inflammation
Limits:
Animals
/
Humans
Language:
En
Journal:
Nat Cell Biol
Year:
2024
Document type:
Article
Affiliation country:
Singapore
Country of publication:
United kingdom