Pharmacological Modulation of Cognitive Test Solution in Mice of Two Genotypes.

ABSTRACT

Mice of two strains selected for successful solution of "object permanence" test and for lack of such solution demonstrated the differential reaction to injections of two drugs. The effects of injections of atomoxetine. which blocks the noradrenaline reuptake, and of 'non-benzodiazepine" anxiolytic afobazol was different. The success of solutions increased in mice selected for this test "non-solution" and decreased or was inefficient in mice, selected for successful solution of object permanence cognitive test.