Association between 5-HT1A receptor C-1019G, 5-HTTLPR polymorphisms and panic disorder: a meta-analysis.
Aging (Albany NY)
; 16(17): 12293-12311, 2024 Aug 28.
Article
in En
| MEDLINE
| ID: mdl-39207450
ABSTRACT
HTR1A C-1019G polymorphism (rs6295) and serotonin transporter promoter polymorphism (5-HTTLPR) have been linked with panic disorder (PD) in different ethnic backgrounds. Both these polymorphisms are in the promoter regions. However, results are inconsistent and contrasting evidence makes reliable conclusions even more challenging. A meta-analysis was conducted to test whether C-1019G polymorphism and 5-HTTLPR were involved in the etiology of PD. Articles researching the link between C-1019G, 5-HTTLPR polymorphisms, and PD were retrieved by database searching and systematically selected on the basis of selected inclusion parameters. 21 studies were included that examined the relationship of rs6295,5-HTTLPR polymorphisms with PD risk susceptibility (rs62957 polymorphism - 7 articles, and 5-HTTLPR polymorphism - 14 articles). A significant association was seen between the rs6295 polymorphism and PD pathogenesis, especially in Caucasian PD patients. No significant genetic linkage was found between the 5-HTTLPR polymorphism and PD. C-1019G polymorphism was involved in the etiology of PD in Caucasian patients. The 5-HTTLPR polymorphism was not a susceptibility factor of PD.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Panic Disorder
/
Genetic Predisposition to Disease
/
Receptor, Serotonin, 5-HT1A
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Serotonin Plasma Membrane Transport Proteins
Limits:
Humans
Language:
En
Journal:
Aging (Albany NY)
/
Aging (Albany, N.Y. Online)
Journal subject:
GERIATRIA
Year:
2024
Document type:
Article
Affiliation country:
China
Country of publication:
United States