Association between change in heart rate over years and life span in the Paris Prospective 1, the Whitehall 1, and Framingham studies.
Sci Rep
; 14(1): 20052, 2024 08 29.
Article
in En
| MEDLINE
| ID: mdl-39209972
ABSTRACT
Heart rate, a measure of the frequency of the cardiac cycle, reflects the health of the cardiovascular system, metabolic rate, and activity of the autonomic nervous system. Whether changes in resting heart rate are related to lifespan has not yet been explored to our best knowledge. In this study, we examined the association between resting heart rate and lifespan using linear regression in the Paris Prospective Study I, the Whitehall I Study, and the Framingham Heart Study. We used Cox proportional hazards regression to relate changes in heart rate over years to mortality risk. We observed a statistically significant association between increases in resting heart rate over a 5-year period and risk of mortality in the Paris Prospective Study I (HR mortality per 10 bpm increase over time 1.20; 95% CI 1.13 to 1.27) and over an 8-year period in the Framingham Heart Study (HR 1.13; 95% CI 1.07 to 1.19 for men and HR 1.09; 95% CI 1.04 to 1.15 for women), after adjusting for classical risk factors and resting heart rate. Our study shows that men and women who increase their resting heart rate over time increase their risk of mortality.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Heart Rate
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Europa
Language:
En
Journal:
Sci Rep
Year:
2024
Document type:
Article
Affiliation country:
Senegal
Country of publication:
United kingdom