Konjac glucomannan exerts regulatory effects on macrophages and its applications in biomedical engineering.
Carbohydr Polym
; 345: 122571, 2024 Dec 01.
Article
in En
| MEDLINE
| ID: mdl-39227106
ABSTRACT
Konjac glucomannan (KGM) molecular chains contain a small amount of acetyl groups and a large number of hydroxyl groups, thereby exhibiting exceptional water retention and gel-forming properties. To meet diverse requirements, KGM undergoes modification processes such as oxidation, acetylation, grafting, and cationization, which reduce its viscosity, enhance its mechanical strength, and improve its water solubility. Researchers have found that KGM and its derivatives can regulate the polarization of macrophages, inducing their transformation into classically activated M1-type macrophages or alternatively activated M2-type macrophages, and even facilitating the interconversion between M1 and M2 phenotypes. Concurrently, the modulation of macrophage polarization states holds significant importance for chronic wound healing, inflammatory bowel disease (IBD), antitumor therapy, tissue engineering scaffolds, oral vaccines, pulmonary delivery, and probiotics. Therefore, KGM has the advantages of both immunomodulatory effects (biological activity) and gel-forming properties (physicochemical properties), giving it significant advantages in a variety of biomedical engineering applications.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Macrophages
/
Mannans
Limits:
Animals
/
Humans
Language:
En
Journal:
Carbohydr Polym
Year:
2024
Document type:
Article
Affiliation country:
China
Country of publication:
United kingdom