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Coconut milk allergenicity: Insight into reducing the affinity of coconut globulin to immunoglobulin E by atmospheric cold plasma.
Chen, Yang; Chen, Yile; Li, Tian; Wang, Jiamei; Zhang, Weimin.
Affiliation
  • Chen Y; School of Food Science and Engineering, Hainan University, Haikou, Hainan, 570228, China.
  • Chen Y; Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA.
  • Li T; School of Food Science and Engineering, Hainan University, Haikou, Hainan, 570228, China.
  • Wang J; School of Food Science and Engineering, Hainan University, Haikou, Hainan, 570228, China.
  • Zhang W; School of Food Science and Engineering, Hainan University, Haikou, Hainan, 570228, China.
Food Chem X ; 23: 101732, 2024 Oct 30.
Article in En | MEDLINE | ID: mdl-39239533
ABSTRACT
Atmospheric cold plasma (ACP) presents a promising method for the sterilization of coconut milk and exhibits a modifying effect on coconut globulin (CG), the primary allergen in coconut milk. This study investigated the potential role of ACP treatment in mitigating the allergenic properties of coconut milk by examining changes in protein structure. ACP treatment induced structural alterations in CG, disrupting binding sites with immunoglobulin E (IgE). Consequently, this led to a reduction in the affinity between CG and IgE, evidenced by a decrease in Ka from 2.17 × 104/M to 0.64 × 104/M, thereby diminishing IgE-mediated allergic reactions. The findings from allergenic and cellular models further corroborated that ACP treatment decreased the allergenicity of CG by 55.18%, while inhibiting degranulation and the release of allergic mediators. This study presents an innovative methodology for producing hypoallergenic coconut milk, thereby expanding the applicability of ACP technology within the food industry.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Food Chem X Year: 2024 Document type: Article Affiliation country: China Country of publication: Netherlands

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Food Chem X Year: 2024 Document type: Article Affiliation country: China Country of publication: Netherlands