Tunneling Nanotubes in Myeloid Cells: Perspectives for Health and Infectious Diseases.
Results Probl Cell Differ
; 73: 419-434, 2024.
Article
in En
| MEDLINE
| ID: mdl-39242388
ABSTRACT
Tunneling nanotubes (TNTs) are cellular connections, which represent a novel route for cell-to-cell communication. Strong evidence points to a role for TNTs in the intercellular transfer of signals, molecules, organelles, and pathogens, involving them in many cellular functions. In myeloid cells (e.g., monocytes/macrophages, dendritic cells, and osteoclasts), intercellular communication via TNT contributes to their differentiation and immune functions, by favoring material and pathogen transfer, as well as cell fusion. This chapter addresses the complexity of the definition and characterization of TNTs in myeloid cells, the different processes involved in their formation, their existence in vivo, and finally their function(s) in health and infectious diseases, with the example of HIV-1 infection.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cell Communication
/
Myeloid Cells
Limits:
Animals
/
Humans
Language:
En
Journal:
Results Probl Cell Differ
Year:
2024
Document type:
Article
Affiliation country:
France
Country of publication:
Germany