Protection against DSS-induced colitis in mice through FcεRIα deficiency: the role of altered Lactobacillus.
NPJ Biofilms Microbiomes
; 10(1): 84, 2024 Sep 12.
Article
in En
| MEDLINE
| ID: mdl-39266529
ABSTRACT
The role of mast cells (MCs) in ulcerative colitis (UC) development is controversial. FcεRI, the IgE high-affinity receptor, is known to activate MCs. However, its role in UC remains unclear. In our study, Anti-FcεRI showed highly diagnostic value for UC. FcεRIα knockout in mice ameliorated DSS-induced colitis in a gut microbiota-dependent manner. Increased Lactobacillus abundance in FcεRIα deficient mice showed strongly correlation with the remission of colitis. RNA sequencing indicated activation of the NLRP6 inflammasome pathway in FcεRIα knockout mice. Additionally, Lactobacillus plantarum supplementation protected against inflammatory injury and goblet cell loss, with activation of the NLRP6 inflammasome during colitis. Notably, this effect was absent when the strain is unable to produce lactic acid. In summary, colitis was mitigated in FcεRIα deficient mice, which may be attributed to the increased abundance of Lactobacillus. These findings contribute to a better understanding of the relationship between allergic reactions, microbiota, and colitis.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Dextran Sulfate
/
Receptors, IgE
/
Gastrointestinal Microbiome
Limits:
Animals
Language:
En
Journal:
NPJ Biofilms Microbiomes
Year:
2024
Document type:
Article
Affiliation country:
China
Country of publication:
United States