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Genetic Risk, Lifestyle Adherence, and Risk of Developing Hyperuricaemia in a Japanese Population.
Takase, Masato; Nakaya, Naoki; Nakamura, Tomohiro; Kogure, Mana; Hatanaka, Rieko; Nakaya, Kumi; Chiba, Ippei; Tokioka, Sayuri; Kanno, Ikumi; Nochioka, Kotaro; Tsuchiya, Naho; Hirata, Takumi; Narita, Akira; Obara, Taku; Ishikuro, Mami; Ohseto, Hisashi; Uruno, Akira; Kobayashi, Tomoko; Kodama, Eiichi N; Hamanaka, Yohei; Orui, Masatsugu; Ogishima, Soichi; Nagaie, Satoshi; Fuse, Nobuo; Sugawara, Junichi; Kuriyama, Shinichi; Matsuda, Biobank Japan Project Koichi; Izumi, Yoko; Kinoshita, Kengo; Tamiya, Gen; Hozawa, Atsushi; Yamamoto, Masayuki.
Affiliation
  • Takase M; Graduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
  • Nakaya N; Graduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
  • Nakamura T; Tohoku Medical Megabank Organization, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
  • Kogure M; Tohoku Medical Megabank Organization, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
  • Hatanaka R; Kyoto Women's University, Kyoto, Japan.
  • Nakaya K; Graduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
  • Chiba I; Tohoku Medical Megabank Organization, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
  • Tokioka S; Graduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
  • Kanno I; Tohoku Medical Megabank Organization, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
  • Nochioka K; Graduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
  • Tsuchiya N; Tohoku Medical Megabank Organization, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
  • Hirata T; Graduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
  • Narita A; Tohoku Medical Megabank Organization, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
  • Obara T; Graduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
  • Ishikuro M; Tohoku Medical Megabank Organization, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
  • Ohseto H; Graduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
  • Uruno A; Tohoku Medical Megabank Organization, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
  • Kobayashi T; Graduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
  • Kodama EN; Tohoku Medical Megabank Organization, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
  • Hamanaka Y; Tohoku University Hospital, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
  • Orui M; Graduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
  • Ogishima S; Tohoku Medical Megabank Organization, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
  • Nagaie S; Tohoku Medical Megabank Organization, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
  • Fuse N; Human Care Research Team, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Sakae-cho, Itabashi-ku, Tokyo, Japan.
  • Sugawara J; Graduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
  • Kuriyama S; Tohoku Medical Megabank Organization, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
  • Matsuda BJPK; Graduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
  • Izumi Y; Tohoku Medical Megabank Organization, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
  • Kinoshita K; Graduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
  • Tamiya G; Tohoku Medical Megabank Organization, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
  • Hozawa A; Graduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
  • Yamamoto M; Tohoku Medical Megabank Organization, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Rheumatology (Oxford) ; 2024 Sep 13.
Article in En | MEDLINE | ID: mdl-39271169
ABSTRACT

OBJECTIVE:

To investigate the inter-relationships among genetic risk, healthy lifestyle adherence, and hyperuricaemia susceptibility.

METHODS:

This prospective cohort study was conducted with 7,241 hyperuricaemia-free individuals aged ≥ 20 years from the Tohoku Medical Megabank Community-based cohort study. A comprehensive lifestyle score included body mass index, smoking, drinking, and physical activity, and a polygenic risk score (PRS) was constructed based on uric acid loci from a previous genome-wide association study meta-analysis. A multiple logistic regression model was used to estimate the association between genetic risk, healthy lifestyle, and hyperuricaemia incidence and calculate the area under the receiver operating characteristic curve (AUROC). Hyperuricaemia was defined as a uric acid level ≥7.0 mg/dl or a self-reported history of hyperuricaemia.

RESULTS:

Of the 7,241 adults (80.7% females; mean [SD] age 57.7 [12.6] years), 217 (3.0%) developed hyperuricaemia during 3.5 years of follow-up. Genetic risk correlated with hyperuricaemia development (P for interaction = 0.287), and lifestyle risks were independently associated. Those with a high genetic risk and poor lifestyle had the highest risk (odds ratio 5.34; 95% confidence interval [CI] 2.61-12.10). Although not statistically significant, incorporating the PRS in the model with lifestyle information improved predictive ability (AUROC = 0.771, 95% CI 0.736-0.806 for lifestyle; AUROC = 0.785, 95% CI 0.751-0.819 for lifestyle and PRS; p = 0.07).

CONCLUSION:

A healthy lifestyle to prevent hyperuricaemia, irrespective of genetic risk, may mitigate the genetic risk. Genetic risk may complement lifestyle factors in identifying individuals at a heightened hyperuricaemia risk.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Rheumatology (Oxford) Journal subject: REUMATOLOGIA Year: 2024 Document type: Article Affiliation country: Japan Country of publication: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Rheumatology (Oxford) Journal subject: REUMATOLOGIA Year: 2024 Document type: Article Affiliation country: Japan Country of publication: United kingdom