[Causal relationship between sleep phenotype and idiopathic normal pressure hydrocephalus: a two-sample bidirectional Mendelian randomization study].
Nan Fang Yi Ke Da Xue Xue Bao
; 44(8): 1612-1619, 2024 Aug 20.
Article
in Zh
| MEDLINE
| ID: mdl-39276058
ABSTRACT
OBJECTIVE:
To explore the causal relationship between sleep phenotype and idiopathic normal pressure hydrocephalus (iNPH) using two-sample bidirectional Mendelian randomization.METHODS:
The exposure data including 8 sleep phenotypes used in this study were obtained from GWAS catalog, FinnGenR10 and MRCIEU GWAS. The outcome data for idiopathic normal-pressure hydrocephalus were obtained from FinnGen R10. We used the inverse-variance weighted (IVW) method to perform the principal analyses. Cochrane Q-statistics test was used to assess the heterogeneity and MR Eggerintercept test performed to evaluate the pleiotropy for sensitivity analyses.RESULTS:
IVW result showed that frequent daytime nap was associated with higher odds of iNPH (OR=3.3393, 95 CI% 1.0646-10.4742, P=0.0270). Cochrane Q-statistics test and MR Eggerintercept test showed that the MR analysis had no pleiotropy or heterogeneity (P > 0.05). The external validation reproduced this result (OR=2.5660, 95 CI% 1.1680-5.6373, P=0.0189; OR=4.0424, 95 CI% 1.5709-10.4024, P=0.0038). Reverse Mendelian randomization suggested that iNPH did not have significant impact on sleep phenotype.CONCLUSION:
The frequency of daytime naps is causally associated with iNPH, and reducing the frequency of weekly daytime naps can reduce the risk of iNPH in the elderly population.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phenotype
/
Sleep
/
Mendelian Randomization Analysis
/
Hydrocephalus, Normal Pressure
Limits:
Humans
Language:
Zh
Journal:
Nan Fang Yi Ke Da Xue Xue Bao
Year:
2024
Document type:
Article
Country of publication:
China