Endoplasmic reticulum stress in abdominal aortic aneurysm.
Int J Cardiol Heart Vasc
; 54: 101500, 2024 Oct.
Article
in En
| MEDLINE
| ID: mdl-39280692
ABSTRACT
Abdominal aortic aneurysms (AAAs) are characterized by permanent dilatation of the abdominal aorta, which is accompanied by inflammation, degradation of the extracellular matrix (ECM) and disruption of vascular smooth muscle cell (VSMC) homeostasis. Endoplasmic reticulum (ER) stress is involved in the regulation of inflammation, oxidative stress and VSMC apoptosis, all of which are critical factors in AAA development. Although several studies have revealed the occurrence of ER stress in AAA development, the specific biological functions of ER stress in AAA development remain largely unknown. Given that targeting ER stress is a promising strategy for treating AAAs, further investigation of the physiological and pathological roles of ER stress in AAA development is warranted.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Int J Cardiol Heart Vasc
Year:
2024
Document type:
Article
Country of publication:
Ireland