Adaptive physiological and metabolic alterations in Staphylococcus aureus evolution under vancomycin exposure.
World J Microbiol Biotechnol
; 40(10): 322, 2024 Sep 16.
Article
in En
| MEDLINE
| ID: mdl-39283509
ABSTRACT
Staphylococcus aureus can develop antibiotic resistance and evade immune responses, causing infections in different body sites. However, the metabolic changes underlying this process are poorly understood. A variant strain, C1V, was derived from the parental strain C1 by exposing it to increasing concentrations of vancomycin in vitro. C1V exhibited a vancomycin-intermediate phenotype and physiological changes compared to C1. It showed higher survival rates than C1 when phagocytosed by Raw264.7 cells. Metabolomics analysis identified significant metabolic differences pre- and post-induction (C1 + SC1 vs. C1V + SC1V 201 metabolites) as well as pre- and post-phagocytosis (C1 vs. SC1 50 metabolites; C1V vs. SC1V 95 metabolites). The variant strain had distinct morphological characteristics, decreased adhesion ability, impaired virulence, and enhanced resistance to phagocytosis compared to the parental strain. Differential metabolites may contribute to S. aureus ' resistance to antibiotics and phagocytosis, offering insights into potential strategies for altering vancomycin nonsusceptibility and enhancing phagocyte killing by manipulating bacterial metabolism.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phagocytosis
/
Staphylococcus aureus
/
Vancomycin
/
Metabolomics
/
Anti-Bacterial Agents
Limits:
Animals
Language:
En
Journal:
World J Microbiol Biotechnol
Year:
2024
Document type:
Article
Affiliation country:
China
Country of publication:
Germany