The utility of splicing factor SRSF1 in gliomas grading: A meta-analysis.
Tunis Med
; 102(9): 513-520, 2024 Sep 05.
Article
in Fr
| MEDLINE
| ID: mdl-39287342
ABSTRACT
INTRODUCTION:
The grading of glial tumors is based on morphological and sometimes on molecular features. Many markers have been assessed in order to grade the glial tumours without a real consensus. Some authors reported that SRSF1, a spiling factor, presents an expression correlated to the tumours grades.AIM:
In this study, we aimed to assess the utility of the SRSF1 into the grading of gliomas based on its immunohistochemical expression.METHODS:
The authors conducted a meta-analysis under the PRISMA guidelines during a 10-year-period (2013-2023). The Meta-Disc software 5.4 (free version) was used. Q test and I2 statistics were carried out to explore the heterogeneity among studies. Meta-regression was performed in case of significant heterogeneity. Publication bias was assessed using the funnel plot test and the Egger's test (free version JASP).RESULTS:
According to the inclusion criteria, 4 studies from 193 articles were included. The pooled SEN, SPE and DOR accounted respectively for 0.592, 0.565 and 1.852. The AUC was estimated to 0.558 suggesting a bad diagnostic accuracy. The heterogeneity in the pooled SEN and SPE was statistically significant. The meta-regression analysis focusing on the technique used, the clones, the dilution, the interpretation technique revealed no covariate factors (P>0.05).CONCLUSION:
Even if this meta-analysis highlighted the absence of a real diagnostic utility of the SRSF1 in grading the glial tumours, the heterogeneity revealed reinforces the need for more prospective studies performed according to the quality assessment criteria.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain Neoplasms
/
Biomarkers, Tumor
/
Neoplasm Grading
/
Serine-Arginine Splicing Factors
/
Glioma
Limits:
Humans
Language:
Fr
Journal:
La tunisie med
/
La tunisie medicale
/
Tunis Med
Year:
2024
Document type:
Article
Country of publication:
Tunisia