Can Serum Fetuin-A be Used as a Marker for Cardiovascular Involvement in Psoriatic Patients?
J Psoriasis Psoriatic Arthritis
; 8(2): 66-73, 2023 Apr.
Article
in En
| MEDLINE
| ID: mdl-39296671
ABSTRACT
Background:
Psoriasis is a systemic inflammatory disorder. It is associated with increased risk of developing other chronic health diseases such cardiovascular disorders. Fetuin A is a glycoprotein that is present in blood serum. It may prevent vascular calcification by forming calciprotien particles; which are formed from their attachment with phosphate and calcium complexes.Aim:
The aim of this study was to measure serum Fetuin A in Psoriatic patients and correlate its level with cardiac events and risks in these patients using CT calcium (Ca) scoring. Patients andMethods:
24 psoriatic patients (healthy without apparent cardiac risks to detect subclinical events if present) and 24 age and sex matched controls were tested for serum Fetuin A and underwent coronary calcium scoring by multidetector computed tomography (CT) scan. Psoriasis area and severity index (PASI) score for each patient was measured and was correlated with serum Fetuin A and CT calcium (Ca) scoring. Serum Fetuin A was compared between cases and controls and was correlated with coronary calcium score.Results:
There was highly statistically significant decrease in serum Fetuin A level in psoriatic group compared to control group (P-value < .001). There was highly statistically significant negative correlation between calcium score and the level of serum Fetuin A (P-value < .001). No statistically significant correlation was found between the serum level of Fetuin A and the psoriasis severity.Conclusion:
Serum Fetuin A is a simple, easy diagnostic tool to evaluate subclinical atherosclerosis in psoriatic patients.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
J Psoriasis Psoriatic Arthritis
Year:
2023
Document type:
Article
Affiliation country:
Egypt
Country of publication:
United States