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Sulfa-Michael Addition on Dehydroalanine: A Versatile Reaction for Protein Modifications.
Li, Man; Li, Mengzhao; Geng, Hongen; Chen, Linfeng; Xu, Ludan; Li, Xiang; Liu, Chunrong.
Affiliation
  • Li M; National Key Laboratory of Green Pesticide, College of Chemistry, Central China Normal University, Wuhan 430079, China.
  • Li M; School of Pharmacy, Hubei University of Science and Technology, Xianning 437100, China.
  • Geng H; Hubei Engineering Research Center of Traditional Chinese Medicine of South Hubei Province, Xianning 437100, China.
  • Chen L; National Key Laboratory of Green Pesticide, College of Chemistry, Central China Normal University, Wuhan 430079, China.
  • Xu L; National Key Laboratory of Green Pesticide, College of Chemistry, Central China Normal University, Wuhan 430079, China.
  • Li X; National Key Laboratory of Green Pesticide, College of Chemistry, Central China Normal University, Wuhan 430079, China.
  • Liu C; National Key Laboratory of Green Pesticide, College of Chemistry, Central China Normal University, Wuhan 430079, China.
Org Lett ; 26(39): 8329-8334, 2024 Oct 04.
Article in En | MEDLINE | ID: mdl-39311466
ABSTRACT
Chemical modification of proteins has been widely applied in diagnostic and therapeutic processes. Here, we report a novel bioconjugation between sulfinic acids and amino acid dehydroalanine (Dha) in the context of both small molecules and proteins. This conjugation enables the rapid formation of sulfone linkages in a chemoselective and disulfide-compatible manner under biocompatible conditions with Dha residues chemically installed in proteins and thus provides a robust tool that is simple and has exquisite site selectivity for protein functionalization in a wide range.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proteins / Alanine Language: En Journal: Org Lett / Org. lett / Organic letters Journal subject: BIOQUIMICA Year: 2024 Document type: Article Affiliation country: China Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proteins / Alanine Language: En Journal: Org Lett / Org. lett / Organic letters Journal subject: BIOQUIMICA Year: 2024 Document type: Article Affiliation country: China Country of publication: United States