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How can quantum computing be applied in clinical trial design and optimization?
Doga, Hakan; Bose, Aritra; Sahin, M Emre; Bettencourt-Silva, Joao; Pham, Anh; Kim, Eunyoung; Andress, Alan; Saxena, Sudhir; Parida, Laxmi; Robertus, Jan Lukas; Kawaguchi, Hideaki; Soliman, Radwa; Blankenberg, Daniel.
Affiliation
  • Doga H; IBM Quantum, Almaden Research Center, San Jose, CA, USA. Electronic address: hakandoga@ibm.com.
  • Bose A; IBM Research, Yorktown Heights, NY, USA.
  • Sahin ME; The Hartree Centre, STFC, Sci-Tech Daresbury, Warrington, UK.
  • Bettencourt-Silva J; IBM Research, Dublin, Ireland.
  • Pham A; Deloitte Consulting LLP, Atlanta, GA, USA.
  • Kim E; Deloitte Consulting LLP, Morristown, NJ, USA.
  • Andress A; Deloitte Consulting LLP, Philadelphia, PA, USA.
  • Saxena S; GNQ Insilico Inc., Pleasanton, CA, USA.
  • Parida L; IBM Research, Yorktown Heights, NY, USA.
  • Robertus JL; Imperial College London and Royal Brompton and Harefield Hospitals, London, UK.
  • Kawaguchi H; Keio University, Yokohama, Japan.
  • Soliman R; GNQ Insilico Inc., Boston, MA, USA.
  • Blankenberg D; Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Trends Pharmacol Sci ; 45(10): 880-891, 2024 Oct.
Article in En | MEDLINE | ID: mdl-39317621
ABSTRACT
Clinical trials are necessary for assessing the safety and efficacy of treatments. However, trial timelines are severely delayed with minimal success due to a multitude of factors, including imperfect trial site selection, cohort recruitment challenges, lack of efficacy, absence of reliable biomarkers, etc. Each of these factors possesses a unique computational challenge, such as data management, trial simulations, statistical analyses, and trial optimization. Recent advancements in quantum computing offer a promising opportunity to overcome these hurdles. In this opinion we uniquely explore the application of quantum optimization and quantum machine learning (QML) to the design and execution of clinical trials. We examine the current capabilities and limitations of quantum computing and outline its potential to streamline clinical trials.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quantum Theory / Research Design / Clinical Trials as Topic / Machine Learning Limits: Humans Language: En Journal: Trends Pharmacol Sci / Trends in pharmacological sciences / Trends pharmacol. sci Year: 2024 Document type: Article Country of publication: United kingdom

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quantum Theory / Research Design / Clinical Trials as Topic / Machine Learning Limits: Humans Language: En Journal: Trends Pharmacol Sci / Trends in pharmacological sciences / Trends pharmacol. sci Year: 2024 Document type: Article Country of publication: United kingdom